Case Report

Jod-Basedow phenomenon: Reactivation of thyroid eye disease after contrast computed tomography

Roland Hollhumer, Francesca Indiveri
African Vision and Eye Health | Vol 77, No 1 | a436 | DOI: | © 2018 Roland Hollhumer, F. Indiveri | This work is licensed under CC Attribution 4.0
Submitted: 13 November 2017 | Published: 12 September 2018

About the author(s)

Roland Hollhumer, Department of Ophthalmology, University of the Witwatersrand, South Africa
Francesca Indiveri, Department of Ophthalmology, University of the Witwatersrand, South Africa


To report a case of Jod-Basedow phenomenon, where a patient with quiescent thyroid eye disease became active after a contrast computed tomography (CT). A patient with clinically inactive thyroid eye disease underwent a contrast CT, after which her clinical activity score increased for 1 to 6/10 with optic nerve dysfunction. She was managed medically with intravenous steroids, neomercazole and propranolol. Jod-Basedow phenomenon is a rare condition where thyroid eye disease reactivates after a large iodine bolus. It is important for clinicians to be aware of this when considering special investigations, such as contrast scans, where iodine is given in large doses.


Thyroid eye disease; Jod Basedow phenomenon; contrast scan; iodine; proptosis


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