Original Research

Regression of an asymptomatic choroidal metasta- sis from breast carcinoma following letrozole therapy*

Jayshan Yohendran, Devinder Chauhan
African Vision and Eye Health | South African Optometrist: Vol 68, No 4 | a165 | DOI: https://doi.org/10.4102/aveh.v68i4.165 | © 2009 Jayshan Yohendran, Devinder Chauhan | This work is licensed under CC Attribution 4.0
Submitted: 13 December 2009 | Published: 17 December 2009

About the author(s)

Jayshan Yohendran, Royal Victorian Eye and Ear Hospital, South Africa
Devinder Chauhan, Vision Retinal Institute, South Africa

Full Text:



Background: Uveal metastases are commonly of breast origin, typically affecting the posterior choroid. Treatment of such uveal tumours can lead to significant ocular side effects.

Methods: We present the clinical and optical coherence tomography findings of a patient with an asymptomatic choroidal metastases.

Results: A 62-year-old lady presented with an asymptomatic uniocular choroidal metastases from breast origin. She was being treated with letrozole, a nonsteroidal aromatose inhibitor, for known pleural metastases. The choroidal lesion was inactive at presentation to our clinic and required no further treatment.

Conclusion: The use of letrozole can lead to choroidal metastasis regression.


Choroidal metastasis; letrozole; breast carcinoma; aromatase inhibitors


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