Review Article
Polyol pathway: A possible mechanism of diabetes complications in the eye
Submitted: 03 September 2014 | Published: 29 April 2015
About the author(s)
Solani D. Mathebula, Department of Optometry, University of Limpopo, South AfricaAbstract
Keywords
Metrics
Total abstract views: 26199Total article views: 39460
Crossref Citations
1. Ameliorative Influence of Dietary Fenugreek (Trigonella foenum-graecum) Seeds and Onion (Allium cepa) on Eye Lens Abnormalities via Modulation of Crystallin Proteins and Polyol Pathway in Experimental Diabetes
Seetur R. Pradeep, Krishnapura Srinivasan
Current Eye Research vol: 43 issue: 9 first page: 1108 year: 2018
doi: 10.1080/02713683.2018.1484146
2. Biomedical Applications of Polyurethane Hydrogels, Polyurethane Aerogels,
and Polyurethane-graphene Nanocomposite Materials
Saganuwan Alhaji Saganuwan
Central Nervous System Agents in Medicinal Chemistry vol: 22 issue: 2 first page: 79 year: 2022
doi: 10.2174/1871524922666220429115124
3. 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development
Sandra K. Urbaniak, Karolina Boguszewska, Michał Szewczuk, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
Molecules vol: 25 issue: 1 first page: 202 year: 2020
doi: 10.3390/molecules25010202
4. Molecular complexities underlying the vascular complications of diabetes mellitus – A comprehensive review
Shalini Paul, Azam Ali, Rajesh Katare
Journal of Diabetes and its Complications vol: 34 issue: 8 first page: 107613 year: 2020
doi: 10.1016/j.jdiacomp.2020.107613
5. Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy
Amna Parveen, Jin Hyun Kim, Byeong Gyu Oh, Lalita Subedi, Zahra Khan, Sun Yeou Kim
Molecules vol: 23 issue: 7 first page: 1519 year: 2018
doi: 10.3390/molecules23071519
6. Aldose Reductase: a cause and a potential target for the treatment of diabetic complications
Sapna Thakur, Sonu Kumar Gupta, Villayat Ali, Priyanka Singh, Malkhey Verma
Archives of Pharmacal Research vol: 44 issue: 7 first page: 655 year: 2021
doi: 10.1007/s12272-021-01343-5
7. Molecular pathways of oxidative stress in diabetes: redox imbalance and insulin pathway dysregulation
Zahid Ahmad Wani, Asvene Kumar Sharma, Showkeen Muzamil, Mehak Nasser Mir, Ishfaq Ahmad Malik, Rayees Ahmad Naik, Shuja Shafi Malik, Irfan Ashraf Badroo, Aabid Rashid Hurra, Yaqoob lone
Molecular Biology Reports vol: 53 issue: 1 year: 2026
doi: 10.1007/s11033-025-11389-z
8. The Usefulness of Serum Sorbitol and Vascular Endothelial Growth Factor A in Predicting Diabetic Retinopathy as Compared to Optical Coherence Tomography
Sanaa Gadbaan Hama Almandlawi, Muhanad Salah Mawlood
Open Medicine Journal vol: 6 issue: 1 first page: 41 year: 2019
doi: 10.2174/1874220301906010041
9. Polyol pathway and redox balance in diabetes
Sourbh Suren Garg, Jeena Gupta
Pharmacological Research vol: 182 first page: 106326 year: 2022
doi: 10.1016/j.phrs.2022.106326
10. Computational Insights into Aldose Reductase Inhibition by Soy Isoflavones: A Pathway To Diabetes Mitigation
Md. Nazim Uddin, Miah Roney, Jie Wang, Mohd Fadhlizil Fasihi Mohd Aluwi, Md. Mamunur Rashid
Journal of Pharmaceutical Innovation vol: 21 issue: 1 year: 2026
doi: 10.1007/s12247-025-10254-7
11. Metabolic Dysregulation and Neurovascular Dysfunction in Diabetic Retinopathy
Thangal Yumnamcha, Michael Guerra, Lalit Pukhrambam Singh, Ahmed S. Ibrahim
Antioxidants vol: 9 issue: 12 first page: 1244 year: 2020
doi: 10.3390/antiox9121244
12. Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World
Ashay D. Bhatwadekar, Aumer Shughoury, Ameya Belamkar, Thomas A. Ciulla
Genes vol: 12 issue: 8 first page: 1200 year: 2021
doi: 10.3390/genes12081200
13. Risk Factors for Cataracts in Patients with Diabetes Mellitus
Adriana Ivanescu, Simona Popescu, Laura Gaita, Oana Albai, Adina Braha, Romulus Timar
Journal of Clinical Medicine vol: 13 issue: 23 first page: 7005 year: 2024
doi: 10.3390/jcm13237005
14. Signature precursor and mature microRNAs in cervical ripening during gestational diabetes mellitus lead to pre-term labor and other impediments in future
R. Vedika, Priyanshy Sharma, Amala Reddy
Journal of Diabetes & Metabolic Disorders vol: 22 issue: 2 first page: 945 year: 2023
doi: 10.1007/s40200-023-01232-2
15. Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease
Yuechang Wang, Yonggang Zhang, Wei Wang, Yanmin Zhang, Xueqian Dong, Yang Liu
Metabolites vol: 15 issue: 3 first page: 210 year: 2025
doi: 10.3390/metabo15030210
16. Amplitude of accommodation is reduced in pre-presbyopic diabetic patients
Solani David Mathebula, Prisilla Seipati Makunyane
Journal of Endocrinology, Metabolism and Diabetes of South Africa vol: 22 issue: 1 first page: 12 year: 2017
doi: 10.1080/16089677.2017.1316955
17. From Painkillers to Antidiabetics: Structural Modification of NSAID Scaffolds for Drug Repurposing
Anđela Gogić, Miloš Nikolić, Nikola Nedeljković, Nebojša Zdravković, Marina Vesović, Ana Živanović
Future Pharmacology vol: 6 issue: 1 first page: 2 year: 2026
doi: 10.3390/futurepharmacol6010002
18. Modulation of Oxidative Stress in Diabetic Retinopathy: Therapeutic Role of Natural Polyphenols
Verónica Gómez-Jiménez, Raquel Burggraaf-Sánchez de las Matas, Ángel Luis Ortega
Antioxidants vol: 14 issue: 7 first page: 875 year: 2025
doi: 10.3390/antiox14070875
19. A review of the molecular mechanisms of hyperglycemia‐induced free radical generation leading to oxidative stress
Habib Yaribeygi, Stephen L. Atkin, Amirhossein Sahebkar
Journal of Cellular Physiology vol: 234 issue: 2 first page: 1300 year: 2019
doi: 10.1002/jcp.27164
20. Exploring Diabetic Retinopathy: Pathogenesis, Therapeutic Advances, and Genetic Influences
Lavanya B. Ramegowda, Saurabh Maheshwari, Shobha C. Ramachandra, Swetha N. Kempegowda, Prashant Vishwanath, Akila Prashant
Current Ophthalmology Reports vol: 13 issue: 1 year: 2025
doi: 10.1007/s40135-025-00331-y
21. In vitro antioxidant, antiglycation, and MGO scavenging effects of Leonurus sibiricus water extract
Xiu Qing Chong, Kirtani AP Anamalay, Okechukwu Patrick Nwabueze, Hor Kuan Chan
Asia Pacific Journal of Molecular Biology and Biotechnology first page: 84 year: 2021
doi: 10.35118/apjmbb.2021.029.4.08
22. HIV-pharmacotherapy and pathogenesis of diabetes-induced cardiovascular complications: an updated narrative review
Khanyisa Maswanganyi, Andile Khathi, Mlindeli Gamede
Cardiovascular Research vol: 122 issue: 4 first page: 446 year: 2026
doi: 10.1093/cvr/cvag036
23. Exploring the Potential of Isoindole‐1,3‐Dione Derivatives as Novel Inhibitors of Aldose Reductase: An In Silico and In Vitro Insight into Therapeutic Strategies for Diabetic Complications
Bülent Şengül, Özlem Gündoğdu, Namık Kilinç, Nurhan Kishali
ChemistrySelect vol: 9 issue: 36 year: 2024
doi: 10.1002/slct.202401852
24. Screening inhibitory effects of selected flavonoids on human recombinant aldose reductase enzyme: in vitro and in silico study
Veysel Comakli, Sevki Adem, Aykut Oztekin, Ramazan Demirdag
Archives of Physiology and Biochemistry vol: 128 issue: 5 first page: 1368 year: 2022
doi: 10.1080/13813455.2020.1771377
25. Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
Marco Greco, Anas Munir, Debora Musarò, Chiara Coppola, Michele Maffia
Frontiers in Neuroscience vol: 17 year: 2023
doi: 10.3389/fnins.2023.1244022
26. Anti-Diabetic Potential of Polyphenol-Rich Fruits from the Maleae Tribe—A Review of In Vitro and In Vivo Animal and Human Trials
Magdalena Rutkowska, Monika A. Olszewska
Nutrients vol: 15 issue: 17 first page: 3756 year: 2023
doi: 10.3390/nu15173756
27. Virtual screening for chemical analogues similar to phytochemicals that inhibit aldose reductase in the development of diabetic microvascular complications
Filex Otieno, Richard Kagia
F1000Research vol: 12 first page: 314 year: 2023
doi: 10.12688/f1000research.129663.1
28. Hypertension potentiates cataractogenesis in rat eye through modulation of oxidative stress and electrolyte homeostasis
Samsroz Ahmad Khan, Rajesh Choudhary, Amrita Singh, Surendra H. Bodakhe
Journal of Current Ophthalmology vol: 28 issue: 3 first page: 123 year: 2016
doi: 10.1016/j.joco.2016.05.001
29. Bioengineered Polymer/Composites as Advanced Biological Detection of Sorbitol: An Application in Healthcare Sector
Ruma Rani, Geeta Singh, Kanisht Batra, Prasad Minakshi
Current Topics in Medicinal Chemistry vol: 20 issue: 11 first page: 963 year: 2020
doi: 10.2174/1568026620666200306131416
30. Anticataract Effects of Methanol Extract of Ocimum sanctum L. Leaf on In Vitro Glucose-induced Goat Eye Lens Model
Ujjval P. Vaghela, Darshit Vadera, Bansi Vyas, Ashvin Rathod, Dhrumil Chhayani, Krupa Hirpara, Kushal Parekh, Vishvesh Kanabar, Pratik Vediya, Dilsar Gohil
Journal of Natural Remedies first page: 1415 year: 2025
doi: 10.18311/jnr/2025/48625
31. Plumbagin protects against cataract formation in STZ-induced diabetic rats: Establishing insights into the molecular mechanism
Apurva Yadav, Rajesh Choudhary, Anshul Ram, Umashankar Nirmalkar, Jaya Shree, Swarnali Das Paul, Vinay Sagar Verma
Experimental Eye Research vol: 263 first page: 110792 year: 2026
doi: 10.1016/j.exer.2025.110792
32. Inhibition of glycation and aldose reductase activity using dietary flavonoids: A lens organ culture studies
Kapil K. Patil, Rajesh N. Gacche
International Journal of Biological Macromolecules vol: 98 first page: 730 year: 2017
doi: 10.1016/j.ijbiomac.2017.01.129
33. Silymarin from Milk Thistle Fruits Counteracts Selected Pathological Changes in the Lenses of Type 1 Diabetic Rats
Weronika Borymska, Maria Zych, Sławomir Dudek, Ilona Kaczmarczyk-Sedlak
Nutrients vol: 14 issue: 7 first page: 1450 year: 2022
doi: 10.3390/nu14071450
34. Natural aldose reductase inhibitors for treatment and prevention of diabetic cataract: A review
Nour Elhouda Daoudi, Omar Bouziane, Mohamed Bouhrim, Mohamed Bnouham
Herba Polonica vol: 68 issue: 1 first page: 35 year: 2022
doi: 10.2478/hepo-2022-0002
35. Implementation and evaluation of a team approach to managing diabetes mellitus and diabetic retinopathy in the South African district health system
Zaheera Abdool, Kovin Naidoo, Linda Visser
African Vision and Eye Health vol: 80 issue: 1 year: 2021
doi: 10.4102/aveh.v80i1.570
36. Inhibitory effect of Nifedipine on aldose reductase delays cataract progression
Alaparthi Malini Devi, Venu Sankeshi, Arugonda Ravali, Srinivas Bandaru, Vinay Kumar Theendra, Someswar Rao Sagurthi
Naunyn-Schmiedeberg's Archives of Pharmacology vol: 397 issue: 1 first page: 161 year: 2024
doi: 10.1007/s00210-023-02588-1
37. Endogenous advanced glycation end products in the pathogenesis of chronic diabetic complications
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Frontiers in Molecular Biosciences vol: 9 year: 2022
doi: 10.3389/fmolb.2022.1002710
38. Polyphenol-Rich Extract of Apocynum venetum L. Leaves Protects Human Retinal Pigment Epithelial Cells against High Glucose-Induced Damage through Polyol Pathway and Autophagy
Jun Peng, Rahima Abdulla, Xiaoyan Liu, Fei He, Xuelei Xin, Haji Akber Aisa
Nutrients vol: 16 issue: 17 first page: 2944 year: 2024
doi: 10.3390/nu16172944
39. The role of branched chain aminotransferase in the interrelated pathways of type 2 diabetes mellitus and Alzheimer’s disease
Haya Majid, Sunil Kohli, Sajad Ul Islam, Nidhi
Journal of Diabetes & Metabolic Disorders vol: 24 issue: 1 year: 2025
doi: 10.1007/s40200-025-01597-6
40. The near reflex evaluation in diabetic patients without retinopathy
B Guner Sonmezoglu, B. Çakır, H.I. Sonmezoglu
Journal Français d'Ophtalmologie vol: 48 issue: 7 first page: 104579 year: 2025
doi: 10.1016/j.jfo.2025.104579


