Original Research

Intraocular pressure following 18 hours of systemic dehydration in ocular normotensive healthy subjects

Faustina K. Idu, Gladys O. George, Leonard F.O. Obika
African Vision and Eye Health | Vol 74, No 1 | a10 | DOI: https://doi.org/10.4102/aveh.v74i1.10 | © 2015 Faustina K. Idu, Gladys O. George, Leonard F.O. Obika | This work is licensed under CC Attribution 4.0
Submitted: 03 September 2014 | Published: 23 July 2015

About the author(s)

Faustina K. Idu, Department of Optometry, University of Benin, Nigeria
Gladys O. George, Department of Optometry, University of Benin, Nigeria
Leonard F.O. Obika, Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Nigeria


Aim: To investigate the effect of dehydration on intraocular pressure (IOP). Subjects: The study population comprised 50 subjects (27 men and 23 women) with a mean age of 42.84 ± 2.64 years.

Method: The subjects dehydrated for 18 hours. IOP was assessed in both eyes using the Perkins handheld applanation tonometer. Baseline measurement of IOP was taken before the subjects dehydrated for 18 hours and repeated after dehydration. Blood samples were taken before and after dehydration for the determination of plasma osmolality and plasma antidiuretic hormone (ADH) concentrations.

Results: A statistically significant (p < 0.001) reduction in the mean weight of subjects occurred after dehydration. There was a significant reduction in IOP from 16.68 mmHg ± 0.32 mmHg to 13.08 mmHg ± 0.31 mmHg after dehydration (p < 0.001). Mean plasma osmolality showed a statistically significant increase (p < 0.05) from baseline of 290.02 mOsmol/kg ± 1.25 mOsmol/kg to 294.96 mOsmol/kg ± 1.33 mOsmol/kg after dehydration. There was also a significant increase (p < 0.05) in mean plasma ADH concentration from 5.36 pg/mL ± 0.21 pg/mL to 6.40 pg/mL ± 0.20 pg/mL after dehydration. There were no significant differences in both systolic and diastolic blood pressures before and after dehydration.

Conclusion: Dehydration decreases IOP in healthy humans; this decrease probably results from an increase in plasma osmolality and plasma ADH concentrations.


intraocular pressure; plasma osmolality; antidiuretic hormone; blood pressure; dehydration


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Crossref Citations

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